I find printing directly from layout to be a real problem, it never gets it right. I can only imagine that the sheer size of my layout files are way too much for my printers. I've had up to 50 meg files and I just don't have the memory in the printer to handle that.
I always export to pdf then print but even then, there are some problems which, thankfully can usually be solved. My models are always in hybrid mode which tends to make huge pdfs, like 50+ megs big ( which could explain why the printer can't handle that) BUT to fix this, inside adobe acrobat you can reduce the file size which reduces the pdf so much it boggles my mind. I've had a file go from 74 megs to 5 megs. I don't know what it's doing but it works and I don't lose quality of the file.
BUT the problem is that sometimes after all of that the print still doesn't work, it prints one of the images and no lines or 4 out of 5 pages are fine and one is messed up even though the pdf looks fine. I traced those types of problems to missing reference files or ones that need updates, so see if your references are correct. Other than that I'm not sure.
jsteacy