I'd say trial them all to find the one that ticks the most boxes.
Quantifier and ProfileBuilder are probably the most cost efficient and customisable. But you do need both to be the most productive.
PlusSpec doesn't have the same parametric abilities that ProfileBuilder does but automates others areas very cleverly. It does alot more than PB3/Q Pro though.
MeDeek I'm not too familar with. He does have a bevvy of tools to pick from.
There's FlexTools too. Its focus is Dynamic Components based responsive modelling so its very non-destructive.
In short, I've not really answered your query...... 😕