Installed SU 2022 and everything went smoothly. Copied my SU 2021 plugins and only had to re-enter my Medeek licenses.
Everything else is working fine with what I checked so far: Profile Builder 3, Thea Render; Instant Architect; Cloth Works; Medeek Wall, Foundation and Truss; and Skatter 2. Seems a little faster.
The Tag tool is really handy to change objects, groups or components to the tag your currently set on and works like a "magic wand."