Hi folks.
On my Macs, I position the Large Tool Set on the left with all other tool palettes that I can get from the View Menu. For other tools or palettes, like the Layers's one, I right click on the tool area on top to access the whole tool collection and the I customise it by dragging what is needed there.
Of course, space being limited in this upper area, using floating tool palettes, that can be positionned around the modeling window is a viable solution.
Notice that the Mac Large Tool Set is more complete than the PC Large Tool Set. On PC, I disable this and enable everything else except the Dimension Window (old VCB) that I leave attached to the right end of the Status Bar.
Just ideas.