I think the next version of Blender [3] will be the one where the UI is addressed.
The old 'we use right mouse button' to save the user from experiencing repetitive strain is proving to be the biggest adoption issue for users.
But, compared with 2.4, the latest is pretty friendly if you ask me.
The amount of dxf/dwg files created in NURB apps that I get these days mean it is impossible to use SketchUp. In Blender I import, re-topo, UV map, export to SketchUp and probably reduce file size by 70-80%
I wouldn't say I'm a Blender fanboy but in terms of possibilities Blender is immense.