Placing the model's geometry miles from the SKP origin will surely cause issues.
If you have CAD data imported then switch all visible/layers-on and unlocked... and move everything a know amount nearer to the origin X,Y [note it down - you can use it later to move new updated imports into place too...]
If you have CAD blocks made into components you might also have components with very remote insertion-points/axes relative to their geometry... so there could be nested objects appearing weirdly...