2022 and I am having the same problem as OP. I've read two threads on this but can't find an answer that works. I've attached a one-page version of my file with all images, viewports, and file links removed to reduce file size.
LAYOUT SETTINGS:
Document Setup/Paper: 11" w x 8.5" h
Document Setup/Paper: 1/4" margins all around
Page Setup/Format for: I tried "Any Printer" and "Canon MX470 Series", which is the only printer I have. I also went through all the settings for my printer and don't see anything saying, print off center. And nothing else does prints off center, just Layout.
Page Setup: US Letter. I tried portrait and landscape (why are these even options since I set height and width in doc setup?).
EXPORT ATTEMPTS:
Exported to PDF (my normal process): output skewed to left. Screenshot of output and of PDF export options attached.
File/Print: output skewed to left. Screenshot of settings with print preview attached.
File/Print/Save as PDF: output skewed to left.
Export to JPG (or PNG): this works fine! So my workaround for this deadline was to export my entire document to PNGs, open the files in Photoshop, and export a multipage PDF. But I would really like not to go through that again, especially for longer documents.
SYSTEM
Layout 2021 (21.1.331)
Mac OS Monterrey 12.1 (And although it's not relevant to this post, I'll add my voice to the chorus of Mac users begging for the Sketchup Default Tray option!)
Any help greatly appreciated!
Export to JPG.jpg
PDF export options.png
File Print Settings.png