Jim makes some excellent comments.
I addition, I would suggest that you make each piece that you would make in the shop, a component. For example the case sides should each be instances of the same component. Currently, the sides themselves are not components at all. The same goes for the front and rear base trim. While the side base trim pieces are components, they could be instances of the same component which would be more efficient. The same goes for the drawer sides
If you want to get accurate dimensions out of your model, you might want to take a look at aligning mating components. The drawers seem to need a bit of attention in that area. The lower drawer as drawn is too tall for its opening. If you follow the dimensions as drawn, you'll wind up with some troubles when you try to fit the drawer.
I'm curious about why you have the global axes repositioned--notice in Jim's screen shots that the green axis is up. It's the blue one that should be up and the red running from left to right across the front of the model. Many of the component axes seem to be in strange locations, too. This leads me to think you're working too hard.
Tomot makes the point that you don't really need the dust panel between the drawers. He's right. You don't. Although I doubt there'd be much of a cost saving in leaving it out. It doesn't need to be as thick as you made it of course. If you do opt to remove it, my suggestion would be to add traditional runners which would act as kickers at the bottom. I think that would look nicer than setting runners in the sides of the case and having exposed grooves plowed in the sides.
If you're going to dovetail the drawer sides into the front, why not dovetail the back into the sides as well? You might want to cut the drawer back so the bottom panel can slide in after the box is assembled. Put a groove on the inside of the drawer front to receive the bottom and fasten the bottom to the back with a single screw. Run the grain on the bottom panel across the width of the drawer and put a slot in for the screw so the bottom can expand and contract with seasonally without trying to push the box apart.
I would leave the legs off the sides of the case and set it into a rabbet around the top of the base. Some small corner blocks can be used to strengthen the corners.
Keep plugging away.