Thanks Dan!
Bummer about EntityID, but I think assigning my own Unique ID can work for my purpose.
"MyBox" will always be a basic cube, and I am fine with only detecting if origin of other entities are within the bounds of "MyBox", sounds like that wont be difficult.
I'm sure I will have future questions, so let me give a better idea what I am trying to accomplish. For starters, check out this short video of my AutoCAD version of the plugin(Hopefully you can get the jist despite poor quality video).
Bascially this is what I like to call an "Option Solving Engine". The idea is to let the user "Graphically Program" Architectural Design Options within a SketchUp model, and give the ability to "Resolve" this model for any number of selected option configurations. Each time the model is "Resolved" it will first be copied in order to keep original model intact.