We use the last generation iMac 27" i5 with the ATI 4850 video card. We experienced zero problems and we literally run SU 10 hours a day with 20-30 different plugins and 100mb site models. In fact I'll be heading to grad school in a month and I plan to buy the same computer for my extensive SU use.
Caveat: I have a Thinkpad t60 with ATI Firegl card and it has all sorts of weird display issues. Its my understanding that ATI and SU problems where mostly limited to the past.